[2] At the start of World War One the flotilla was reassigned to the new Grand Fleet and was engaged at the Battle of Jutland[3] it remained with the GF until September 1916 when it was transferred to the Humber Force that was receiving shore support from the Humber Station till December 1916.

After being ordered to leave Portsmouth it was reassigned to the Commander-in-Chief, Devonport where it remained till November 1918.

[7] It stays with the East Indies Fleet until November 1944 then is ordered back to Europe to join forces in the Mediterranean Sea until 1946.

It transfers back to home waters where it stays until March 1951 it was re-designated the 4th Destroyer Squadron.

The unit reforms again as part of the Mediterranean Fleet Note: Command structure organizational changes took place within Royal Navy post war period the term Flotilla was previously applied to a tactical unit until 1951 which led to the creation of three specific Flag Officers, Flotillas responsible for the Eastern, Home and Mediterranean fleets the existing destroyer flotillas were re-organized now as administrative squadrons.