Elements of the regiment fought at Pea Ridge, Whitney's Lane, Little Blue River, Byram's Ford, Westport, Marais des Cygnes, Marmiton River, and Mine Creek.

The 4th Missouri Cavalry Regiment was organized in February 1862 and mustered in for three years by consolidation of the Fremont Hussars and three companies of the Hollan Horse.

The regiment was mustered in under the command of Colonel George E. Waring, Jr.

District of Columbus, Kentucky, 6th Division, XVI Corps, Department of the Tennessee, to December 1863.

1st Brigade, 2nd Cavalry Division, District of West Tennessee, to December 1864.