Judson Memorial Church, located at the corner of Thompson Street and Washington Square South, was designed by architect Stanford White and stained glass master John La Farge.

The infamous Golden Swan bar (known as the "Hell Hole"), at the corner of Sixth Avenue, was a famous haunt of Eugene O'Neill and the setting and inspiration for his play The Iceman Cometh.

Reed later worked in a room in the Studio Club building to complete the series of articles that became his account of the Bolshevik Revolution, Ten Days That Shook the World, later the source for the film Reds.

[8] It started the careers of such artists as Ashcan School painter John Sloan, Edward Hopper, whose first one-man exhibit was held there in 1920, and social realists Reginald Marsh and Isabel Bishop.

Louis Abolafia, the 1968 hippie candidate for the presidency, had his artists' studio and campaign headquarters at 129 East 4th St. Music venue The Bottom Line was at 15th West 4th Street from 1974 to 2004.