The unit fought at the battles of Kernstown, Port Republic, Rappahannock Station, Second Bull Run, Chantilly, Antietam, and Fredericksburg in 1862.

The battery transferred to the Cavalry Corps where it served for the rest of the war.

Artillery, Battery E fought at Chancellorsville, Gettysburg, Culpeper, Bristoe Station, and Mine Run.

In 1864, the unit fought at the Wilderness, Todd's Tavern, Yellow Tavern, Totopotomoy, Cold Harbor, the Wilson-Kautz Raid, Opequon, Fisher's Hill, and Cedar Creek.

In 1865, it saw action at Dinwiddie Court House, Five Forks, Sailor's Creek, and Appomattox before taking part in the Grand Review of the Armies.

Organized at Camp Monroe, Ohio, and joined Rosecrans in West Virginia.

Attached to 2nd Brigade, Army of Occupation, West Virginia, to September, 1861.

Kelly's Command, Railroad District, West Virginia, to January, 1862.

Artillery, Lander's Division, Army of the Potomac, to March, 1862.

Artillery, Shields' 2nd Division, Banks' 5th Army Corps, to April, 1862.

Unattached Artillery, 3rd Corps, Army of Virginia, to September, 1862.

1st Brigade, Horse Artillery, Army of the Potomac, to August, 1864.

Operations at Welford's, Kelly's and Beverly Fords April 14–15.

James City, Bethesda Church and near Culpeper October 10.

Gainesville, New Baltimore, Buckland's Mills and Haymarket October 19.

Riddell's Shop and White Oak Swamp June 13.

Wilson's Raid on Southside & Danville Railroad June 22-July 1.

Expedition from Winchester into Faquier and Loudoun Counties November 28-December 3.

Tabernacle Church or Beaver Pond Creek April 4.

At Antietam, Clark's battery sustained losses of two killed and one wounded.

Five days after the battle, the unit counted one officer and 52 enlisted men.