The 50th North Carolina Infantry Regiment was a volunteer infantry regiment that served in the Confederate Army during the American Civil War and was organized early in the war near Raleigh, North Carolina.

50th Infantry Regiment completed its organization in April 1862, at Camp Mangum, near Raleigh, North Carolina.

Men of this unit were raised in the counties of Person, Robeson, Johnston, Wayne, Rutherford, Moore, and Harnett.

Ordered to Virginia, it fought under General Daniel at Malvern Cliff, then returned to North Carolina.

In November 1864, it moved south and shared in the defense of Savannah, GA and skirmished along the Rivers' Bridge.