The 52nd Illinois General Assembly met from 1921 to 1923.

Fred E. Sterling of Rockford was the Lieutenant Governor of Illinois and thus ex officio President of the Senate.

[a] William S. Jewell of Fulton County was President pro tempore of the Senate.

Gotthard A. Dahlberg of Chicago was the Speaker of the House of Representatives.

Illinois was divided into 51 districts, each of which elected one Senator and three Representatives.