The West Wing also set a record with twelve total acting nominations when including the guest category, a category that existed for L.A. Law, but was not available for Hill Street Blues during its second season (1981–82) of nine acting nominations.

In addition, Stockard Channing joined an exclusive club of actors that have won two awards in one ceremony for different roles.

Furthermore, Michael Chiklis became the second actor in a cable network series to win for Outstanding Lead Actor in a Drama Series (after James Gandolfini for The Sopranos in 2000 and 2001) for his performance as Vic Mackey in The Shield whilst becoming FX's first ever acting win.

When Band of Brothers won Outstanding Miniseries, the audience gave a standing ovation to the miniseries' subjects: the soldiers of "Easy" Company, 2nd Battalion, 506th Parachute Infantry Regiment of the 101st Airborne Division, as their surviving members were shown both in the auditorium and on the broadcast at the Los Angeles St. Regis Hotel.

Co-creator and executive producer Steven Spielberg then invited Major Richard "Dick" Winters, their D-Day commanding officer who was played by Damian Lewis in the miniseries and attended the ceremony live, to speak.