More recently he co-starred in the romantic comedy The Big Sick (2017) and portrayed mob lawyer Bill Bufalino in Martin Scorsese's epic crime film The Irishman (2019).

His career included many outlets, such as Comedy Central, where he had been a recurring guest voice on the show Dr. Katz, Professional Therapist.

Shortly thereafter, he became the star of his own show, Everybody Loves Raymond on CBS, that featured a cast and format more suitable to Romano's brand of humor.

[11][12] Romano and his comedian friend Kevin James starred in the salesman comedy Grilled as two average Joes of the same profession who are both desperate to land a big sale.

Romano returned to television with a new dramedy for TNT in 2008, Men of a Certain Age, which he co-created with former Everybody Loves Raymond writer Mike Royce.

[14] Romano made an appearance in the third-season premiere of the ABC sitcom The Middle as Nicky, a friend of Mike, who ruined his and Frankie's honeymoon.

Romano was the second actor from Everybody Loves Raymond to be reunited with Patricia Heaton on The Middle; Doris Roberts guest starred in three episodes.

[15][16] He became a semi regular, playing photographer Hank Rizzoli, who hired and later had a romantic relationship with Sarah Braverman and developed a friendship with her nephew who has Asperger syndrome.

The role was specifically created for him after he expressed his love for the series and met with creator Jason Katims on the set of Friday Night Lights.

From 2017 to 2019, Romano played a leading role in three seasons of the MGM+ television show Get Shorty, created by Davey Holmes and co-starring Chris O'Dowd.

[18] In 2019, Romano starred in the Netflix comedy film Paddleton and portrayed mob lawyer Bill Bufalino in Martin Scorsese's The Irishman.

Romano is also a regular competitor in the AT&T Pebble Beach National Pro-Am, where he finished fifth in 2012 with his partner, Australian professional Steven Bowditch.

He also competes annually in the American Century Championship, a celebrity golf tournament owned by NBC and held at Lake Tahoe[22][23] each July.

Romano's wife, Anna, appeared as one of the moms in the background at Geoffrey and Michael's school in season 6's episode titled "The Angry Family".