[1] The ceremony involved no ticketed audience due to the ongoing COVID-19 pandemic, but featured a limited number of health care workers.

[3] Due to the COVID-19 pandemic, the show followed a similar format to the 55th ceremony, utilizing several locations and including a mix of live and pre-recorded performances.

[4][5] As with the 55th ceremony, presentations took place at the Grand Ole Opry House, Ryman Auditorium, and the Bluebird Café, while performances were also held at The Station Inn, Lower Broadway, and the Cumberland River.

[8][9] The ACM stated that it "does not condone or support intolerance or behavior that doesn't align with our commitment and dedication to diversity and inclusion.

"[10][11] The nominees were announced on February 21, 2021, with Miranda Lambert, Maren Morris and Chris Stapleton leading with four nods each.