In response to the landing at Anzac Cove of Australian and New Zealand forces on 25 April 1915 the 57th Regiment counterattacked, slowed the Allied advance and lost about half of its personnel.

At the commencement of the First Balkan War while the 2nd Battalion was distributed to other units the rest of the regiment remained intact and was assigned to the 19th Infantry Division which was part of the VII Corps of the Vardar Army.

[4][5] On 23 February 1915, Major Hüseyin Avni succeeded Miralay Şemi Bey as commander of the regiment.

The regiment was training at Rodosto when in response to the perceived threats to the Dardanelles the III Corps of which the 19th Division was part was assigned the task of reinforcing the Gallipoli Peninsula.

On 25 February, the regiment arrived at Eceabat (Maydos) by steamship, though its battalions were missing their fourth companies.

[2] Upon landing at Anzac Cove the Allied attackers encountered Turkish soldiers of the No.2 battalion of the 27th Regiment who, after doing what they could, withdrew back over the ridges.

The main Ottoman forces in the area had been held in reserve to see just where the British Empire troops were going to land on the peninsula.

Already woken by the sounds of gunfire a report reached Mustafa Kemal at 5.20 am that an enemy force was scaling the heights at Ariburnu (ANZAC Cove).

The counterattack was successful and drove the Australian forward units under the command of Captain Eric W. Tulloch off Battleship Hill.

During this action which was personally led by Hüseyin Avni the regiment sustained heavy losses over the course of the day but were able to successfully stabilize the right flank of the Turkish defences.

As the campaign turned into a trench war, the regiment was deployed around Merkeztepe-Bombastır and successfully defended this area until the Allied withdraw from Gallipoli.

[10] After the successful completion of the Gallipoli Campaign, the 19th Division including the 57th Regiment was assigned to the newly formed XV Corps.

[2] On 21 August, 1916, Russians began their Brusilov Offensive along the Galicia front which led to the positions occupied by the 57th Regiment being attacked on 11 September.

[2][11] After departing from Galicia the regiment reached the Bakırköy railway station on the outskirts of Istanbul on 23 June 1917 and established itself in tents near İncirli Çiftliği.

[2] On the night of 11-12 September 1917, they encountered Allied forces on the Oatar ridge near the villages of Akir, Al-Mugar and Karta and became involved in heavy combat.

Combat continued on the ridges of Al-Mugar and Karta, in the vicinity of Akir, Ramle, Sheikh Munis, then around Kırmızıtepe, Cülcüliye, Kefer and Sürgüntepe.

[2] In May 2014 construction started on the erection of a mosque on the grounds of the Facility of Theology of the Çukurova University in the city of Adana dedicated to the memory of the regiment.

[13] Partly in response to the increasing number of Australian and New Zealand youth on the battlefields for Anzac Day local Turkish university students organised a commemoration march in 2006.

As the march became more popular the Ministry of Youth and Sports assumed some control of the event and the government began funding the cost of travel and living expenses for its participants.