599 Lexington Avenue is a 653 ft (199m) tall, 50-story skyscraper in Midtown Manhattan, New York City, designed by Edward Larrabee Barnes/John MY Lee Architects.

[3] It was the first building constructed by Mortimer Zuckerman and his company Boston Properties in New York City.

The building is adjacent to the Citigroup Center and is considered a well-designed contextual partner to the area.

[4] The property also contains an entry to the Lexington Avenue/51st Street station of the New York City Subway, served by the 6, <6>​​, E, and ​M trains.

The project's lead architect Bruce Fowle was a protegé of Edward Larrabee Barnes, the building's original designer.