The story involves a student at a convent who undergoes a radical transformation after consuming strange "mushrooms".

Raised there since childhood, her uneventful life takes a turn when she secretly eats some unusual mushrooms given to her by Oaxacan Indians.

Brenda crashes a party at a high-society family's home, where she meets wealthy university students Luis, Pablo, Alberto, Bernardo, and Miguel, the only one who calls her Domitila.

Led by Brenda, the group quickly becomes a gang of mischief-makers, pulling off various pranks throughout Mexico City.

The commissioner of the International Surveillance Agency is determined to capture the "dangerous subversive" leader of the gang.