The programme got its name from the approximate time the show started on a Saturday evening – six minutes past six – following Sports Report.

[3] Under Baker in the 1990s the show favoured bizarre and obscure but amusing topics, often avoiding the matches played and headline football news.

However, from Mellor onwards, the show became established as a more mainstream phone-in, mainly focusing on Premier League teams.

From the 2016–17 season, the Saturday team changed, with Jason Mohammad joining Savage, due to Fletcher's BT Sport commentary commitments.

From the 2020–2021 season, Robbie Savage transitioned to the presenter role for both the Saturday and Sunday shows, alongside Chris Sutton.

Celebrity fans so far have included Ray Winstone (West Ham United), Alan Davies (Arsenal), Beverley Knight (Wolves), Norman Jay (Spurs), Trevor Nelson (Chelsea), Tony Jeffries (Sunderland) and James and Oliver Phelps aka Fred and George Weasley from the Harry Potter films (Birmingham City and Aston Villa).

Other features on their show included, "ABB" in which both Bruce-Ball and Sutton share what has "Amused", "Bugged" and "Baffled" them during the week, and, "The Simulation Game" in which they play a clip of the song "Free Fallin'" by Tom Petty and also play the commentary from the times during the week when players have been caught diving.

Since Robbie Savage took over as presenter, features include "six times six", giving six callers, six seconds to state their name, the team they support and their point, as well as "Gone in 60 Suttons".

In addition to the phone-in programme, there was also an online version of 606 in the form of an internet message board, although in June 2006 the site was forced to temporarily close due to the large amount of web traffic and forum threads.

On 24 January 2011, it was announced the 606 forum would close at the end of the 2010–11 football season, due to cuts in the BBC's online budget of 25% .