It was organized on 1 June 1917 at the Presidio of San Francisco, California, from personnel of the 12th Infantry Regiment, and was assigned to the 11th Division on 5 July 1918.

The 63rd Infantry was inactivated at Plattsburg Barracks and disbanded 31 July 1922.

It was reconstituted in the Regular Army on 10 May 1941, activated 1 June 1941 at Fort Leonard Wood, Missouri, and concurrently assigned to the 6th Infantry Division.

The regiment was inactivated on 10 January 1949 in Korea, activated on 4 October 1950 at Fort Ord, California, and inactivated for a final time on 3 April 1956 at Fort Ord.

The 63rd Infantry was originally organized in California and after World War I performed guard duty in New York state.