It fought the Japanese invaders in the island from April 18, 1942, to May 12, 1942, after ordered to surrender by Visayas-Mindanao Force commander Major General William F. Sharp.

The regiment participated in the Operation Baus Au initiated by General Chynoweth before he was ordered to assumed command of the new Visayas Force base in Cebu.

The 64th Infantry was assigned to Capiz Province to thwart any Japanese landings but Naval and Air bombardment prevented them to do so due to absence of a single artillery gun in the Island.

However, this did not prevent Kawamura Detachment turnover Panay to 10th Independent Garrison to leave for Mindanao.

On May 12, 1942, Colonel Christie surrendered his Division to the Japanese forces in Cabatuan, Iloilo.