The regiment completed formation on December 18, 1862, but would not be called into active service until June 27, 1863, under the command of Colonel Edwin Wilmer.
During the middle of 1862, President Abraham Lincoln issued a request for 300,000 men to join the Union Army as 90-day volunteers.
[5] After mobilizing, the regiment was sent to Havre de Grace, Maryland, where it guarded the Philadelphia, Wilmington and Baltimore Railroad[6] near the Susquehanna River.
[6] The regiment had been mobilized in part due to a perceived threat to the region, and also to guard an influx of prisoners of war that had arrived at Fort Delaware.
[8] Besides Havre de Grace, the 6th Delaware also guarded the railroad at the Bush and Back Rivers and the Maryland towns of Gunpowder and Perrymansville.