It was last assigned to the 451st Strategic Missile Wing at Lowry Air Force Base, Colorado, where it was inactivated on 25 June 1965.

After training in the United States, it deployed to the Mediterranean Theater of Operations, where it participated in the strategic bombing campaign against Germany.

The squadron commander, Captain James B. Beane, and a model crew joined other members of the group for advanced tactical training with the Army Air Forces School of Applied Tactics at Orlando Army Air Base, Florida.

The ground echelon left on 26 November for the port of embarkation at Camp Patrick Henry, Virginia, for transportation by ship.

[6] The squadron functioned primarily as a strategic bombing unit, attacking various targets including oil refineries, marshalling yards, aircraft factories and airfields in Italy, Germany, France, Czechoslovakia, Austria, Bulgaria, Hungary, Romania, Greece and Albania.

It earned a Distinguished Unit Citation during Big Week for an attack on a Messerschmitt aircraft factory at Regensburg, Germany, on 25 February 1944.

It added oak leaf clusters to this award for an attack on oil refineries and marshalling yards at Ploesti, Romania, on 5 April 1944 and on Markersdorf-Haindorf Airfield near Vienna, Austria, on 23 August 1944.

[7][b] When returning from the Regensburg attack, runway conditions at Gioia del Colle were so poor that the aircraft of the 451st Group were unable to land there, but spread out among a number of bases in Italy.

[16][17] On 19 November 1964, Defense Secretary Robert McNamara announced the phase-out of the remaining first-generation SM-65 Atlas and Titan I missiles by the end of June 1965.