The Squadron's lineage dates back to World War II, as the 705th Tank Destroyer Battalion which was attached to the 502nd Infantry Regiment.

1-75 CAV is noted for locating and destroying multiple weapons caches as well as detaining several ranking members of Al-Qaeda in Iraq.

In January 2006 the Squadron was moved to protect a deadly Main Supply Route (MSR) leading into Baghdad.

1-75 CAV returned to Iraq in support of Operation Iraqi Freedom in October 2007 and redeployed to Fort Campbell in late November 2008.

[3] 1-75 CAV, along with the rest of the Strike Brigade and the 101st Airborne Division Headquarters, received orders to deploy to eastern Europe in support of Operation Assure, Deter and Reinforce in May 2022[4] to replace elements of 3rd Brigade, 82nd Airborne Division that deployed as the Immediate Response Force earlier that year in response to Russian aggression in Europe.

[8] Charlie Troop deactivated several months before the rest of the squadron in March 2024, with its personnel being transferred to activate the 2BCT Multi-Functional Reconnaissance Company (MFRC).

11 series MOS (Infantry) enlisted men and officers man the mortar sections and dismounted recon troop.