It served in the Eastern Theater, most notably in the battles of Chancellorsville and Gettysburg and then in the siege operations against Charleston, South Carolina.
The infantry regiment was organized at Camp John McLean near Cincinnati, Ohio, from November 7, 1861, to January 8, 1862, to serve three years.
The 75th OVI then participated in the subsequent Northern Virginia Campaign and fought in the Second Battle of Bull Run, where it lost 113 men.
During the battle, the XI Corps was far from the Confederate army, so their commander, Maj. Gen. Oliver O. Howard did not have them dig defenses in case of an attack despite being ordered to do so by Maj. Gen. Joseph Hooker.
Unfortunately, this slight rise in the terrain was too far forward in comparison to the other XI Corps divisions, and Barlow's position formed a salient that could be attacked from multiple sides.
Harris led his men in a successful withdrawal through the hotly contested streets to Cemetery Hill, where they entrenched on the northeastern slope.
[3] In August, the 75th OVI was transferred to Charleston Harbor, remaining in the trenches in South Carolina until September.
The second is on Wainwright Avenue (approximating the former brickyard lane) on East Cemetery Hill (their position on the Second Day).
[2] A monument to the 75th Ohio Volunteer Regiment exists at Camp John McLean Memorial Park in Wyoming, OH, dedicated in 2001.
The site memorializes the training camp grounds for the regiment between October 1861 and January 1862, organized by Nathaniel McLean and Robert Reily.