[8] Robert Reily is considered the "Father of Wyoming" with men and women gathering at his home one week prior to the start of the Civil War in 1861 choosing the name of the village - Wyoming, a Delaware Indian term meaning "large plains.

Good transportation is an integral part of Wyoming's history and the leading reason for its prosperity.

[9] The city lies near the old pre-statehood road associated with Anthony Wayne that connected Cincinnati with locations farther north, such as Fort Hamilton and Fallen Timbers.

Curves in the road were cut off in 1806 forming Springfield Pike through central Wyoming, later a toll road established by farmers Burns, Riddle, and Pendery of the Hamilton, Springfield, and Carthage Turnpike Company.

[9] In 1828, another mode of transportation became significant in the Miami and Erie Canal, built a short distance to the east.

[9] With wide adoption of automobiles in the early 20th century, the Wright Highway and Mill Creek Expressway eventually became Interstate 75 (I-75) by the mid-20th century to present, which primarily runs through the Ohio Department of Transportation right-of-way; originally the Miami and Erie Canal and its locks east of Wyoming.

[10] Because of Wyoming's proximity to the thriving 19th century industry in Lockland, its easy transportation to the booming city of Cincinnati during the Gilded Age, and its pleasant scenery, many wealthy industrialists purchased local farms and built grand country houses.

[9] Over multiple generations, early farms subdivided and additional areas were annexed into the city forming a primarily residential, pedestrian-scale bedroom community with emphasis on its educational and community-oriented values, culture, and assets.

Wyoming was the first community in the State of Ohio to implement a systematic laying of concrete sidewalks.

[11] The proximity of the lumber mills along the Miami and Erie Canal and influence of original settlers and neighboring communities created the distinct New England weatherboard character; with the most notable historic vista in the Village Historic District lying along Worthington Avenue just south of Wyoming Ave.[9] In the early 1900s, proximity to the railroad lines added many Sears Modern Homes ("kit homes"), and other similar manufacturers, that shipped the building components via railroad boxcars to be assembled on site, having been selected by owners through mail order catalog.

[11] Other styles such as ranch homes, contemporary, mid-century modern, and others became prominent in the Wyoming Hills area as intensive suburban development occurred after World War II.

[13] According to the United States Census Bureau, the city has a total area of 2.87 square miles (7.43 km2), all land.

The city and school district sponsors many community events throughout the year including May Fete, the Wyoming Art Show, Fourth of July Parade and Celebration, Fall Festival, Homecoming, Light Up Wyoming, and others.

Wyoming is served by a branch of the Public Library of Cincinnati and Hamilton County.