On the second day of the battle, Col. Wickliffe was mortally wounded when the regiment was ordered to reinforce the left flank of their brigade.
Gen. George Maney stated, "I directed Colonel Wickliffe, of the Seventh Kentucky, who rendered me most efficient service by his activity and gallantry, the re-enforce[ment of] our left.
He did as directed and received his fatal wound at the head of a charge, doing his whole duty as a devoted patriot and gallant soldier."
Following Shiloh, the 7th Kentucky Infantry moved south and participated in the Corinth Campaign and the Battle of Baton Rouge.
The 7th Kentucky Infantry were en route to Bragg at Tullahoma, Tennessee, when they were ordered to reinforce Lt. Gen. John C. Pemberton in the defenses of Vicksburg, Mississippi.