The unit was created in March 1937 in the eastern sector of the Teruel front, employing a battalion of the POUM, anarchist militiamen of the First Confederal Column and regular troops.[n.

On 14 December it attacked the nationalist positions in the Port of Escandón —which it managed to cross on the 16 December—, continuing its advance towards Teruel along the Sagunto highway, occupying the towns of Castellar and Castralvo.

On 22 December, after eliminating the nationalist resistance in El Mansueto, the brigade took the San Julián neighborhood and the railway station by storm; On the afternoon of the same day, it also took over the Fuente del Torico.

During the Battle of Alfambra the unit had a highly disputed performance in the defense of Sierra Palomera,[8] which it lost to the enemy offensive.

Furthermore, in its retreat the 82nd Mixed Brigade suffered so many casualties that in the end, when it reorganized in the rear, its size had been reduced to just one battalion.