He published a number of botanical works, including continuations of the Prodromus[1] in collaboration with his son, Casimir de Candolle.

[4] He is also known for a study of the religious affiliations of foreign members of the French and British Academies of Science during the Scientific Revolution that demonstrated that in both academies Protestants were more heavily represented than Catholics by comparison with catchment populations.

The natural sciences had become highly specialized, yet this book synthesized them to explain living organisms within their environment, and why plants were distributed the way they were, all upon a geologic scale.

[5] Alphonse de Candolle also had the unexpected distinction of triggering the adoption of pre-paid postage in the Canton and City of Geneva, by a long address which he gave to the governing council in 1843.

This led to them issuing Switzerland's second postage stamp, the famous Double Geneva later in that year.