In addition to the four high school grades, Leto also hosts adult night services.

Established in 1965 with grades 9-11, which meant that the first graduating class was not until 1967, Leto was the first comprehensive high school in Hillsborough County.

It was "comprehensive" because in addition to the high school academic curriculum, Leto offered several modern vocational options for students.

Although the largest school in Hillsborough County, it originally lacked a gymnasium, a stadium, baseball and softball fields, which were added in the 1970s.

Created in 2013, Collegiate Academy is a magnet program provided by Hillsborough Community College.