[6] The school was guided through its early years by Monsignor John F. Scully, the founding President, and was staffed by diocesan priests, the Dominican Sisters of Adrian, Michigan and dedicated lay personnel.

After spending one year in temporary quarters at Christ the King parish, 230 9th and 10th grade students made their way to the new Tampa Catholic campus.

The plan was changed to provide a coeducational facility, taking into account the already operating Academy of the Holy Names and Jesuit High School.

The early classes were held in eight classrooms with a chemistry-physics-biology laboratory, a home economics room, a library, and an administration area.

This was also the first year TC had a full squad for a football team, playing a schedule of both JV and varsity games.

In 1968, Tampa Catholic became fully accredited by the Southern Association of Colleges and Schools and saw the completion of the north building, chapel, gym, track and baseball diamond, all of which were dedicated by Bishop Charles McLaughlin, of the newly founded Diocese of St. Petersburg.

In 2003 these improvements were completed, including the Archbishop Joseph P. Hurley Science & Technology Center and the Blessed Edmund Rice Chapel.

The center will expand the integration of arts programs in the school's curriculum, helping to attract top teachers and students.