Where the bypass meets the A36 Bath to Salisbury road, they merge for about 3 miles, before the A350 continues south towards Shaftesbury, passing through Crockerton Green and Longbridge Deverill and beneath the A303.

The road passes through the hamlet of Cann and the villages of Compton Abbas, Fontmell Magna, Sutton Waldron, Iwerne Minster and Stourpaine before reaching Blandford Forum.

At Blandford Forum is another bypass built to ease town centre traffic where the A350 crossed and merged with the A354.

The final section crosses the Black Water Channel by the Poole Bridge before terminating at the roundabout on New Harbour Road where the Ferry Port is located.

In December 2023, Wiltshire Council awarded a £20.7 million contract for dualling the remaining sections of the A350 Chippenham bypass.

[10] The council expected it to reduce traffic through Westbury, create more space for cyclists and pedestrians, and improve journey time reliability on the A350 by two minutes.

[9] The scheme, would, by the council's own forecasts, cause increased heavy goods vehicle flow through other West Wiltshire communities, such as Southwick, which already have over twice the HGVs of Westbury.

[11] The council's route, which runs close to the Westbury White Horse, two Sites of Special Scientific Interest, near Salisbury Plain and through a Special Landscape Area, is not included in the Regional Transport Priority for South West England.

[13] It attracted opposition from various environmental and local groups including the White Horse Alliance, the Campaign to Protect Rural England, Woodland Trust, Friends of the Earth, Campaign for Better Transport[14] and Wiltshire Wildlife Trust.

A scheme has been proposed since 2015 to improve the A350 West Ashton/Yarnbrook junction to ease traffic flows at a noted bottleneck.

[19] In June 2021, Wiltshire Council's cabinet resolved to progress an eastern route that starts to the north of Beanacre and meets the A3102 and A365 before rejoining the current A350 south of the town, beyond Bowerhill.

Due to the traffic situation in Bath, Highways England may propose de-listing the current route and adopting the A350 instead; this may release funding for further works between Poole and the M4.