The A374 is a main road in the United Kingdom, one of six A-roads making the border crossing between Devon and Cornwall.

Starting at the Marsh Mills junction of the A38, the A374 heads west into Plymouth, following the course of the River Plym along a section of dual carriageway.

Going westward down the locally notorious Union Street, the road enters Devonport and comes to the River Tamar.

Through the town of Torpoint the road continues, following the River Lynher, through the villages of Antony and Sheviock and on to Polbathic, where the B3249 starts northwards to join the A38, avoiding a low bridge at Trerulefoot roundabout.

[1] The original road designated as the A374, as of 1922, ran from Horton Cross, just north of Donyatt in Somerset, southwards to Colyford in Devon along the route of what is now the A358.