The A49 autoroute is a motorway in France.

The road provides a connection between Romans (Valence) with Grenoble.

The first section was opened in 1991 between the junction with the A48 towards Voreppe and the junction at Tullins (N°11).

Its extension to Romans-sur-Isère was opened in 1992.

This article about road transport in France is a stub.