The A52 autoroute is a 25.3 km long motorway in the Bouches du Rhone departement of southeastern France.

It is a toll road except for the very southern stretch south of the Péage du Pont d'Etoile and is operated by ESCOTA.

When travelling southbound from Aix-en-Provence to Toulon, one must take the exit slip after the Péage du Pont d'Etoile in order to remain on the A52.

The northern section of the A52 was subsequently constructed, joining up with the A8 autoroute creating both a link between Marseille and Nice on the one hand and between Aix-en-Provence and Toulon on the other.

This idea was eventually abandoned in favour of a series of developments of the D560 and in view of the construction of the A57 autoroute which provides a similar link, albeit via Toulon.