The road then proceeds into Prestbury at a 30 mph speed limit, crossing over the Stoke-on-Trent to Manchester Piccadilly railway line.

In Prestbury village, the road veers right at a roundabout and climbs towards Wilmslow, reverting to a 30 mph speed limit.

It goes under the Wilmslow railway viaduct holding the Crewe to Manchester Piccadilly railway line, turns right at a roundabout where the B5166 joins, and runs past Wilmslow town centre to a set of traffic lights where it turns left and becomes Manchester Road.

The road goes down a steep hill to the Oversleyford Bridge over the river Bollin, up afterwards, and through two tunnels under Manchester Airport's runways; since 1960 it has been diverted twice here (its original route survives partly as 'Old Wilmslow Road' through the minor crossroads by the Ringway chapel).

After the tunnels, the road runs to a complex traffic light controlled roundabout junction with the M56 motorway Westbound and Runger Lane (which serves as an access road to Manchester Airport; it then goes under the M56 motorway to a roundabout junction with the M56 northbound.