The A643 is a main road between Leeds and Huddersfield in West Yorkshire, England.

Its eastern end is at the Armley Gyratory roundabout on the western edge of Leeds City Centre.

The road then goes through: to its western end, at junction 23 of the M62 Motorway (Mount Roundabout, Outlane, Huddersfield).

In Leeds, the road is a dual carriageway that links the Armley Gyratory roundabout with the M621 motorway at junction 2.

This road is so called because the A643 originally ended in town of Elland near Halifax.