It is located entirely in the Dutch province of Limburg.

The motorway, 27 km long, connects the Belgian border (A2/E314 road) near Stein with Geleen, Heerlen and the German border (A4 road) near Simpelveld.

Along the entire stretch of the motorway, the European route E314 travels along the A76.

At interchange Ten Esschen, only traffic to and from the western part of the A76 can reach the connecting N281 road.

Exit 6, located approximately 1 km to the east, covers traffic from the eastern part of the A76 towards the N281 but not the other way around.