The Ernest F. Hollings ACE Basin National Wildlife Refuge is a 11,815-acre (47.81 km2) portion of the larger ACE Basin area, and the only portions that are federally protected.

The wildlife refuge is divided into two units: the Edisto River unit and the Combahee River unit.

The following threatened or endangered species are present in the refuge: wood stork This article incorporates public domain material from websites or documents of the United States Fish and Wildlife Service.

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