[1] The South Carolina Highway 802, also known locally as Sams Point Road, serves as the principal highway for Lady's Island and provides the only access to Coosaw Island.

She and her mother, Lady Rebecca Axtell, owned Newington Plantation in present-day Summerville, South Carolina.

[3][4] During the American Civil War, Union forces occupied the islands under the direction of General T. W. Sherman.

As development of Beaufort and surrounding areas began in the last half of the 20th century, the island began to develop former plantation and timber tracts into residential subdivisions.

Commercial development clustered at the intersection of S.C. Highway 802 and U.S. Highway 21 serves Lady's Island, Beaufort, and the surrounding Sea Islands of northern Beaufort County.