[5] A G protein–coupled receptor located on the external cell plasma membrane, it is coupled to Gαs and upregulates levels of cAMP by activating adenylyl cyclase.

[10] Both human and bovine ACTH receptors are synthesized as 297 residue long proteins with 81% sequence homology.

[15] The ACTH receptor plays a role in glucose metabolism when expressed in white adipose cells.

When bound to ACTH, a short-term insulin-resistance occurs, and it stimulates lipolysis via hormone sensitive lipase.

[16] Demonstrated in mice, ACTH promotes lipolysis in response to increased energy demand, notably in times of stress.

It is often used as treatment for infantile spasms, multiple sclerosis, nephrotic syndrome, gout, ulcerative colitis, Crohn's disease, rheumatoid arthritis, and systemic lupus erythematosus.

This is problematic long-term and can lead to ACTH-receptor pathway-related side effects including: Cushing's syndrome, fluid retention, glaucoma, and cardiovascular disorders.