In 2006, the team joined the UCI ProTour, following the signings of big cycling names Francisco Mancebo and Christophe Moreau.

Fassa Bortolo's exit from the competition had freed a licence and AG2R was the only team left vying for the license, as Comunidad Valenciana voluntarily withdrew, while the proposed new team of former Fassa Bortolo sporting director Giancarlo Ferretti turned out to be without financial backing.

Ag2r obtained success in the 2006 Tour de France with a stage win by Sylvain Calzati, and a day in the yellow jersey as leader of the general classification by Cyril Dessel.

Rinaldo Nocentini took the yellow jersey after stage 7 of the 2009 Tour de France after a successful breakaway in which fellow Ag2r-La Mondiale rider Christophe Riblon also took part and earned the daily combativity award.

In 2014, the team had great results at the Tour de France, winning a stage and having Jean-Christophe Péraud taking second place in the overall classification.

[9][10][11] On 15 May 2013 Sylvain Georges tested positive for the banned stimulant Heptaminol and failed to start stage 11 of the 2013 Giro d'Italia.

[14] On 21 May Georges 'B Sample' also tested positive for the stimulant[15] causing the team to voluntarily remove itself from the 2013 Critérium du Dauphiné in accordance with MPCC rules.