Vingegaard defended and increased his lead through the Pyrenees and the final individual time trial to secure the victory.

The 2nd tier general classification (GC) favourites were thought to be Aleksandr Vlasov of Bora–Hansgrohe, and Geraint Thomas and Dani Martínez of Ineos Grenadiers, with longshot favourites including Ben O'Connor, Adam Yates, Enric Mas and Romain Bardet.

[11] Danish rider Magnus Cort of EF Education–EasyPost took all King of the Mountains (KoM) points available in Denmark, collecting enough for him to wear the polka dot jersey until stage 9.

During this run he claimed the record of most consecutive summits won, from former Tour champion and multi-time mountains classification winner Federico Bahamontes.

[12] Sprinter Dylan Groenewegen of Team Jayco–AlUla won the final stage in Denmark, before a transfer day and return to France.

A group of GC contenders made their way up the majority of the climb together, before Vingegaard attacked and only Pogačar could follow.

[17] In a sprint on the final slope, Pogačar overtook Vingegaard to get the stage win and extend his lead to over 30 seconds.

[20][21][22] Media discussed the legitimacy of the protest[23] and the effect that climate change was having on the Tour,[24][25] while other coverage expressed annoyance at the disruption to the race.

[26][27] The second week of the race was affected by an intense heat wave, with several stages having temperatures of around 40 °C (104 °F).

[29] No major attacks by GC contenders occurred on stage 10, the first in the French Alps, however Lennard Kämna who was in the breakaway that finished close to ten minutes ahead of the peloton, came within eleven seconds of taking the yellow jersey from Pogačar.

[33] At the end of the day only six riders were within five minutes of Vingegaard in the overall situation: Bardet, Pogačar, Thomas, Quintana, Yates and Gaudu.

Tom Pidcock of Ineos Grenadiers and former Tour winner Chris Froome, attacked about halfway through the stage and bridged up to the leading breakaway riders.

On the final ascent of Alpe d'Huez, Pidcock attacked from the group including Powless, Froome, Ciccone and Meintjes and rode on to a convincing solo victory.

[41] Brandon McNulty of UAE Team Emirates pulled his teammate Pogačar and Vingegaard up to the final steep slopes of Peyragudes, increasing the gap to the rest of the peloton.

[45][44] Before the ascent of the Hautacam, both riders were caught by a larger group including Thomas and two of Vingegaard's teammates (Sepp Kuss and Tiesj Benoot).

[44] By taking maximum KoM points at the top of Hautacam, Vingegaard gained an unassailable lead of that classification, taking the jersey from Simon Geschke of Team Cofidis, who had set a record for most days by a German rider leading the mountains classification.

[55] In August 2022, Colombian rider Nairo Quintana of Arkéa–Samsic was disqualified from 6th place overall, after blood samples tested positive for tramadol, a painkiller.

[56] a As of 1 March 2022, the UCI announced that cyclists from Russia and Belarus would no longer compete under the name or flag of those respective countries due to the Russian invasion of Ukraine.