Multiple variants were operated by the service, perhaps most noteworthy was the conversion of 40 aircraft to serve as dedicated night fighters.

The ANF Les Mureaux 110 originated with a French air ministry requirement for an aircraft to replace the Breguet 19 in Armée de l'Air service in the "R2" two-seat reconnaissance role.

[3] To optimise for both crew visibility and aerodynamic characteristics, the selected cross section for the aircraft's fuselage was trapezoidal, having a shorter base down and flat sides while both the top and bottom were rounded.

[4] Being largely composed of metal, the fuselage covering comprised strips of duralumin that had a typical width of 20 to 30 cm (7.87 to ll.81 inches); these could be given flanged edges as to permit their riveting together to form sheets.

The structure of the aircraft consisted both spars and longerons as the principal members, which were supported by an array of secondary spars and a channel section frame that were typically placed generally placed perpendicular to the covering strips to which they were riveted to, changing them to closed sections best adapted to withstand local stresses.

[7] The internal structure featured two duralumin spars complete with a lightened web of sheet metal of 0 to 20 mm (0.4 to 0.8 in.)

[8] These spars were of equal thickness to that of the wing with channel sections parallel to them, that were held in position by box crosspieces (instead of conventional ribs) at intervals of roughly one meter (39.37 inches).

[9] The covering strips were placed at right angles to the spars and were riveted to their flanges and to the channel sections, but not to the box crosspieces, to obtain torsional rigidity.

[7] The ailerons, which were relatively narrow and unbalanced, were set into the wing and had differential control in order to reduce the force needed to actuate them.

By the time of the French armistice with Germany on June 25, only 62 aircraft remained intact, some of which were stationed in North Africa.