It is published by Wolters Kluwer on behalf of the American Society for Artificial Internal Organs (ASAIO) and the editor-in-chief is Mark S. Slaughter, MD (University of Louisville).

It was established in 1955 as the Transactions of the American Society for Artificial Internal Organs to publish the proceedings of the annual ASAIO conference.

The journal offers an open access publication option to authors.

In addition, letters to the editors, invited commentaries, case reports, brief communications, and how to do it articles are published free for all to access.

All journal content is free to access one year post-publication.