2340074772ENSG00000159363ENSMUSG00000036622Q9NQ11Q8N4D4Q9CTG6NM_001141973NM_001141974NM_022089NM_001379622NP_001135445NP_001135446NP_071372NP_001135445.1NP_001135446.1NP_001366551Probable cation-transporting ATPase 13A2 is an enzyme that in humans is encoded by the ATP13A2 gene that is involved in the transport of divalent transition metal cations.

[5][6][7] It appears to protect cells from manganese[8] and zinc toxicity,[9] possibly by causing cellular efflux and/or lysosomal sequestration; and from iron toxicity, possibly by preserving lysosome integrity against iron-induced lipid peroxidation.

[10] However, it potentiates the toxic effects of cadmium and nickel on developing neurites,[11] and of the widely used herbicide paraquat[12] possibly by increasing polyamine uptake.

[13] Deficiency is associated with spastic paraplegia and Kufor-Rakeb syndrome, in which there is progressive parkinsonism with dementia.

This article on a gene on human chromosome 1 is a stub.