The film, a domestic comedy, depicts a woman who stops her husband's gambling habit by having her cousin stage a fake police raid on his weekly poker game.

However, his friend Bigelow convinces him to secretly continue attending the weekly poker game and to tell his wife Mary that he has been admitted to the Sons of the Morning, a fraternal lodge, to explain his absences.

[2] A Cure for Pokeritis was one of many Vitagraph's one-reel or shorter comedies starring Bunny and Finch in a domestic setting, known popularly as "Bunnygraphs" or "Bunnyfinches".

During the police raid, depth was demonstrated by having action take place in both the foreground and the background, and by allowing actors to move between the spaces.

[b] The studio suggested either "I Don't Believe You"[c] or "I'm an Honorary Member of the Patsy Club"[d] be played as George presented his purported lodge membership.

His sleep-talking was to be accompanied by "If You Talk in Your Sleep, Don't Mention My Name",[e] followed by "Back to the Factory, Mary"[f] as Freddie investigates.

[27] However, the comedy style of A Cure for Pokeritis has not aged well, especially in contrast to Mack Sennett's slapstick films and the works of later comedians such as Charlie Chaplin and Buster Keaton.

[5][32] Film historian Wes Gehring of Ball State University considers George to be a forerunner of the modern antihero archetype and compares the Browns to Laurel and Hardy.

[34] Brunel University lecturer Geoff King viewed the male lead's efforts to escape from an "imprisoning" wife to be a recurring theme in silent comedy,[35] and film reviewer Peter Nash found the "fastidious and effeminate" Freddie an example of a contemporary gay stock character.