In 1902, Remick and Maurice Shapiro founded Shapiro-Remick & Company, selling several million copies in 1905 of the enormously successful "In the Shade of the Old Apple Tree", written by Harry Williams and Egbert Van Alstyne.
To stay competitive, Remick began to sign up unknown writers such as Harry Warren, Al Dubin, Gus Kahn and Richard A. Whiting, ushering in the golden era of the Roaring Twenties music.
While competing publishing houses were located in Michigan, New York City and Chicago, Jerome H. Remick & Co. held sway in Detroit, also running a successful printing plant from there.
The firm maintained branch offices in New York City and Chicago, with agencies all over the world, and started hundreds of music outlets under the name "Remick Song Shops" throughout the United States.
Remick was an enthusiastic gentleman farmer and owned a 2,200-acre (8.9 km2) estate on Gratiot Avenue, growing fruit and vegetables, and raising chickens.
Remick also served as director on the boards of the pharmaceutical firm Parke-Davis & Co., the Paige Motor Co., the Detroit Savings Bank, and the Union Trust Co.