A Gambler's Anatomy (published as The Blot in the United Kingdom) is a 2016 novel by American author Jonathan Lethem.

The plot concerns Alexander Bruno, a professional backgammon player with "psychic tendencies".

[1] Alexander Bruno is a gambler who encounters a high school friend, Keith Stolarsky, who has made a fortune in real estate.

The novel received mixed reviews,[2] with some praise for the caliber of his writing, and Lethem's ability to combine elements from multiple genres.

[2][3] Dwight Garner referred to Lethem's naming conventions as "Pynchonian" and compared the central antagonist, Keith, to Maurice Conchis, from John Fowles's novel The Magus.