In 1971, Chilton formed the influential power pop group Big Star, a critically acclaimed but commercially unsuccessful band known for its harmonies and jangling guitars.

Chilton's subsequent solo career on small labels drew an intense following among indie and alternative rock musicians.

According to The New York Times, George-Warren's biography addresses questions about Chilton's "wildly different incarnations as a cult figure" whose life and career confounded even the people closest to him, resulting in "a fascinating story, but also an exceptionally knotty one".

"[1] According to Los Angeles Times critic Randall Roberts, "Warren's deep research examines the arc of Chilton's life, uncovers periods of intense focus in famed Memphis studios, including disturbing scenes of a lover's blood on the mixing board and others of Chilton's own blood in bathtubs during suicide attempts.

"[2] Roberts stated, "It's a credit to Warren's unflinching tone that the Chilton of Destruction is a charismatic, oft-frustrating man unwilling to kowtow to anything or anyone... You'll never hear his music the same way again.