On the left is a house called Castlefield that was home to the Borrow family.
There are paintings of Isaac, Thomas and Ann Borrow in Derby Museum and Art Gallery.
Left of centre is Exeter House (demolished in 1854) which, during the Jacobite rising of 1745 played host to Charles Edward Stuart when he decided to turn back with his Scottish armies and not go to London to take the crown.
The large buildings to the right are mills powered by the River Derwent.
The painting was bought by Derby Museum and Art Gallery in 2006 from a European collector via Sotheby's.