The game is set in Europe during the 1890s, and follows a young female opera singer turned vampire as she attempts to make the journey back home to Paris in search of fame and normality.

[3][4] As such, the game uses a point-and-click interface with a context-sensitive radial cursor, much the same as Monkey Island:[5] upon clicking an interactive item, a graphic menu will appear around the object, displaying the available actions and abilities.

[2] In early July 2006 however, Autumn Moon announced that they had finally acquired a new publisher for A Vampyre Story, the Hamburg-based Crimson Cow, and that full production on the game would begin shortly thereafter, stating an expected 2007 release.

[8] The A Vampyre Story Original Soundtrack was composed and produced by Pedro Macedo Camacho,[9] featuring soprano vocals by Carla Isabel Moniz and violin solos by Carlos Freitas.

"[16] A Vampyre Story was intended as the opening chapter of a larger saga, and Autumn Moon Entertainment commenced production on the sequel prior to the game's release.

With the publishing rights to the sequel owned by Crimson Cow, Autumn Moon decided to work independently on an episodic prequel called A Vampyre Story: Year One.

He later considered collaborating with MunkyFun, where he was at the time working as the studio's art director and which had previously been commissioned to assist in the building of Autumn Moon's graphic adventure engine.