He created the games A Vampyre Story and Ghost Pirates of Vooju Island for Autumn Moon Entertainment, a studio he co-founded with Mike Kirchoff in 2002.
Tiller was hired by LucasArts adventure games by Collette Michaud in 1992 as an animator for Brian Moriarty's version of The Dig.
Due to financial issues with the publisher of the Autumn Moon games, Crimson Cow, Tiller has maintained a freelance career in the industry.
Before the success of Snuggle Truck, Tiller served as the art director for MunkyFun, which is itself a studio founded by a number of ex-LucasArts developers.
In August 2014, Bill Tiller began a Kickstarter campaign for a spin-off of Ghost Pirates of Vooju Island titled Duke Grabowski: Mighty Swashbuckler!.