Lead singer Sky Saxon conceptualized the album's cover design depicting the four Seeds members trapped in a spider's web.

[2] Released in October 1966, A Web of Sound did not receive much attention in the United States for several months until after the band's "Pushin' Too Hard", a song from their self-titled debut album, was re-released and entered the Billboard Hot 100 singles chart.

Pete Johnson, in a 1967 Los Angeles Times review, stated that with A Web of Sound, the Seeds had "been adopted by the hippies – the flower children – because of their open-ended songs which generally skirt neatly plotted thoughts and didacticism.

"[2] Some contemporary music critics compare album track "Up In Her Room" to The Velvet Underground song "Sister Ray", which was released a year later.

[9] Researcher/author Martin C. Strong wrote that the album is "full of weird, psychotic blues highlighting [Saxon's] demented vocal sermonizing on such reliable topics as sex, drugs, and rock 'n' roll".