"Can't Seem to Make You Mine" is a song by American rock group the Seeds, written by vocalist Sky Saxon and produced by Marcus Tybalt.

The song appears on the 1998 box set Nuggets: Original Artyfacts from the First Psychedelic Era, 1965–1968, and has been covered by such artists as the Ramones, Alex Chilton, Johnny Thunders, Yo La Tengo, Garbage, and Rumspringa.

"[5] A regional hit in California, the single did not chart nationally until its April 1967 re-release,[4] after the band's "Pushin' Too Hard" had reached the U.S. Top 40.

Music writer Malcolm Russell described the song as "a slow, angry piece which highlighted Saxon's unique vocal style – an inspired nasal snarl punctuated by howls, wails and yelps".

[9] Author Michael Hicks elaborated on Saxon's vocal style on the track: "he superimposes an Eddie Cochran-like buzz on classic Buddy Holly-style baby talk [and] adds a Jagger-like pseudo-dialect, but a seemingly arbitrary one, in which vowels are colored and recolored with no particular consistency.

"[10] The song has been called a "garage rock classic" by authors Will Hodgkinson and Stephen Thomas Erlewine, and it is featured on the 1998 box set Nuggets: Original Artyfacts from the First Psychedelic Era, 1965–1968.