Lopresti was amongst the new creative talent running DC Comics' The New 52 relaunch in 2011, becoming the penciller of the new Justice League International series, working with writer Dan Jurgens.

[5] Since that time, Lopresti has written and illustrated the serialized Garbage Man series for DC Comics which appeared in the anthology miniseries Weird Worlds and My Greatest Adventure and dealt with the adventures of a young corporate lawyer turned toxic muck monster who, according to Lopresti, was created because "the DCU needed a monster/hero character to replace Swamp Thing which at the time was being held captive by Vertigo".

Comics artists that Lopresti has named as influences include Berni Wrightson, Neal Adams, Michael Golden, Jim Steranko, Brian Bolland.

Illustrators who have influenced him include Frank Frazetta, James Bama, William Stout, JC Leyendecker, Brian Froud, Robert McGinnis and Chuck Jones.

[3] Other contemporary artists Lopresti has named as his favorites include Adam Hughes, Travis Charest, Mark Schultz, Mike Ploog, Peter de Sève, Walt Simonson, Alan Davis, Barry Windsor-Smith, Chris Ayers, Claire Wendling, Dave Johnson, Rudy Nebres and Alex Niño.